Protein Info for SM_b21185 in Sinorhizobium meliloti 1021

Annotation: succinate-semialdehyde dehydrogenase (NAD(P)+) protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 34 to 485 (452 residues), 567.7 bits, E=8.1e-175
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 37 to 484 (448 residues), 678.9 bits, E=1.8e-208

Best Hits

Swiss-Prot: 78% identical to GABD_SINFN: Probable succinate-semialdehyde dehydrogenase [NADP(+)] (gabD) from Sinorhizobium fredii (strain NBRC 101917 / NGR234)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to smk:Sinme_4853)

MetaCyc: 59% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

No annotation

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• superpathway of L-arginine and L-ornithine degradation (9/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (7/11 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• 4-hydroxyphenylacetate degradation (3/8 steps found)
• L-lysine degradation III (1/6 steps found)
• nicotine degradation II (pyrrolidine pathway) (3/11 steps found)
• nicotine degradation I (pyridine pathway) (5/17 steps found)
• superpathway of L-lysine degradation (15/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.79

Sequence Analysis Tools

See Q92V65 at UniProt or InterPro

Protein Sequence (491 amino acids)

>SM_b21185 succinate-semialdehyde dehydrogenase (NAD(P)+) protein (Sinorhizobium meliloti 1021)
MALTPALTRHIRRPKIFASLDEVTRSSGQPAGPVFDVSNPSTGELLATLPDMGIDDARTA
IDAAALAQPLWAGKPAKDRSIILRRWHDLIVEHADDLAAILTAEMGKPVGEAKGEVLHAA
SYVEWYAEEAKRVYGETFPAPANDRRMLVIKQPVGVVGTITPWNFPASMVARKISPALAA
GCTIVLKPAEQTPLVAGAMFVLAEKAGFPEGVLNLLYASEGAPIGRELCGNPKVRKISFT
GSTEVGRLLMRQCSDQIKKVSLELGGNAPFIVFDDADIDEAVDGAVQAKFRNAGQTCVSA
NRIYVQSAVHDAFAEKFVTRVRELTVGDGFAPDVAIGPMIDAHAIDKIEAHVADAVAKGA
QVRSGGSRIGTTGTFFEPTVLTGISHDMRIAQEETFGPIAPIIRFETAEQVVAEANDTIY
GLAAYFYAENLKRVWHVAEALEYGMVGINTGRMSSEAAPFGGIKQSGIGREGSRHGLEDY
LEMKYLCMGNI