Protein Info for SM_b21181 in Sinorhizobium meliloti 1021

Annotation: glutaryl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 20 to 132 (113 residues), 134 bits, E=6e-43
• PF02770: Acyl-CoA_dh_M
  • amino acids 136 to 229 (94 residues), 81.9 bits, E=6e-27
• PF00441: Acyl-CoA_dh_1
  • amino acids 242 to 387 (146 residues), 92.3 bits, E=6.9e-30
• PF08028: Acyl-CoA_dh_2
  • amino acids 256 to 376 (121 residues), 24.5 bits, E=5.5e-09

Best Hits

Swiss-Prot: 67% identical to GCDH_CAEEL: Probable glutaryl-CoA dehydrogenase, mitochondrial (F54D5.7) from Caenorhabditis elegans

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 100% identity to smk:Sinme_4857)

MetaCyc: 73% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (3/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

See Q92V67 at UniProt or InterPro

Protein Sequence (395 amino acids)

>SM_b21181 glutaryl-CoA dehydrogenase (Sinorhizobium meliloti 1021)
MAGKSQFQWDDPFLLEDQLSEDERMIRDTARAYAQEKLQPRVTEAYREETTDPSIFREMG
DLGLLGVTVPDTYGGVGASYVAYGLVAREVERVDSGYRSMMSVQSSLVIYPIFAYGSEEQ
KRKYLPKLISGEWIGCFGLTEPDAGSDPAGMKTRAIKTEGGYRLVGSKMWISNAPLADVF
VVWAKSEAHDNAIRGFVLEKGAKGLSAPKIGGKLSLRASITGEIVLDNVEVGEEALLPNV
EGLKGPFGCLNRARYGISWGALGAAEFCWHAARQYGLDRKQFNRPLAQTQLFQKKLADMQ
TEIALGLQGSLRVGRLMDEGRMAPEMISIVKRNNCGKALDIARMARDMHGGNGISEEYQV
MRHMMNLETVNTYEGTHDVHALILGRAQTGLQAFF