Protein Info for SM_b21143 in Sinorhizobium meliloti 1021

Annotation: mercuric reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 PF07992: Pyr_redox_2" amino acids 22 to 334 (313 residues), 202.7 bits, see alignment E=3.1e-63 PF13738: Pyr_redox_3" amino acids 185 to 322 (138 residues), 35.5 bits, see alignment E=2.5e-12 PF00070: Pyr_redox" amino acids 187 to 263 (77 residues), 71.7 bits, see alignment E=2.1e-23 PF02852: Pyr_redox_dim" amino acids 361 to 464 (104 residues), 89.7 bits, see alignment E=5.2e-29

Best Hits

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 100% identity to sme:SM_b21143)

Predicted SEED Role

"PF00070 family, FAD-dependent NAD(P)-disulphide oxidoreductase" in subsystem Mercuric reductase

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.16.1.1

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92V99 at UniProt or InterPro

Protein Sequence (473 amino acids)

>SM_b21143 mercuric reductase (Sinorhizobium meliloti 1021)
MWTTLPPGASISPEVVMNKHFDAVIIGAGQAGPSLAGRLSGVGKTVALIERKLFGGTCVN
TGCMPTKAMVASAYAIHTARRGAEYGMTTGPVSVDFGRVMARKEKVRLDARSGVEKWLKG
MKNCTVFEGHARFEGPREVRIGDELISGERIFVNVGGRAAVADLPGVNDVPYLTNSSIMD
LAELPEHLVVVGGSYIGLEFAQMFRRFGSDVTVIEKGARLIGREDPEVSDAIREILENEG
VRIRTNAECIRFSNHADSVAVGVDCTSGEPEVSGSHVLLATGRHPNTDDLGLDKAGVKTD
ERGYIEVDDSLRTNVPHIFAMGDCNGRGAFTHTSYNDFEIVAANLIDNDPRRVSDRIQTY
ALYIDPPLGRAGMTETEARKKGHKLLVGTRPMTRVGRAVEKGETQGFMKVIVDAETDEIL
GASILGTGGDEAVQSILDVMYAKKPYTMIARAVHIHPTVSELIPTVFGDLSSA