Protein Info for SM_b20892 in Sinorhizobium meliloti 1021

Updated annotation (from data): 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43)
Rationale: Specifically important in carbon source L-Arabinose. Similar to PA2216 from Pseudomonas aeruginosa (see PMC:PMC4038344) and to gguC or araD1 (Atu2345) from Agrobacterium tumefaciens (see PMC: PMC3232879), which also have this activity. In Agrobacterium, this reaction is proposed to be a step in L-arabinose oxidation. (Note that 2-keto-3-deoxy-L-lyxonate and 2-keto-3-deoxy-L-arabinonate are the same compound.)
Original annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20892)

Predicted SEED Role

"SUGAR TRANSPORTER"

MetaCyc Pathways

L-arabinose degradation III (5/6 steps found)
L-lyxonate degradation (2/3 steps found)
superpathway of pentose and pentitol degradation (21/42 steps found)

KEGG Metabolic Maps

Ascorbate and aldarate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.43

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UE5 at UniProt or InterPro

Protein Sequence (331 amino acids)

>SM_b20892 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43) (Sinorhizobium meliloti 1021)
MLISQVRKEDGSVIVAVRAPGETARAVRGAESVYALAMEAANSRRSLRDVVDAKGFGETI
DLEEAYSQGRLLSPITHPDPAHLHLTGTGLTHLGSAATRDAMHKKATEATEETLTDSMKM
FRMGLEGGKPKSGEKGVQPEWFYKGNGTTAVAPGEPLVSPSFAEDGGEEPEMAGIYVISD
KGVPFRLGFAVANEFSDHKTERVNYLWLAHSKLRQASFGPEIRIGAAPEDIRGASRILRG
GKVLWEKPFLSGEANMSHSFANLEYHHFKYGLFRAPGDIHVHMFGTATLSFGDGIRTEEG
DVFEIEAKEFGLPLRNPLAIAAEEEVAVHQL