Protein Info for SM_b20624 in Sinorhizobium meliloti 1021
Annotation: methylthioribose-1-phosphate isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to MTNA_RHIME: Methylthioribose-1-phosphate isomerase (mtnA) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K08963, methylthioribose-1-phosphate isomerase [EC: 5.3.1.23] (inferred from 100% identity to sme:SM_b20624)MetaCyc: 63% identical to methylthioribose-1-phosphate isomerase (Rhodospirillum rubrum)
S-methyl-5-thioribose-1-phosphate isomerase. [EC: 5.3.1.23]; 5.3.1.23 [EC: 5.3.1.23]
Predicted SEED Role
"Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)" in subsystem Methionine Salvage (EC 5.3.1.23)
MetaCyc Pathways
- 5'-deoxyadenosine degradation II (4/4 steps found)
- 5'-deoxyadenosine degradation I (2/3 steps found)
- S-methyl-5-thio-α-D-ribose 1-phosphate degradation III (3/5 steps found)
- S-methyl-5-thio-α-D-ribose 1-phosphate degradation II (2/5 steps found)
- L-methionine salvage cycle II (plants) (4/11 steps found)
- S-methyl-5-thio-α-D-ribose 1-phosphate degradation I (1/7 steps found)
- L-methionine salvage cycle I (bacteria and plants) (4/12 steps found)
- L-methionine salvage cycle III (2/11 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.3.1.23
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92TI2 at UniProt or InterPro
Protein Sequence (364 amino acids)
>SM_b20624 methylthioribose-1-phosphate isomerase (Sinorhizobium meliloti 1021) MKVGDRHYHTIWLNEDGRSVDIIDQRWLPHDLRVVTLKTVADVALAIRDMWVRGAPLIGV TAAYGVAIAMTKDPSDAHLDAVWDELHQTRPTAINLRWALDAMRDHLRPLPEAGRADAAY QRATEIAEEDIELNRAIGANGLKVIRQIAAKKKPGEPVRILTHCNAGWLATVDYGTATAP IYMAVEEGIPVHVYVDETRPRNQGAYLTAWEMSSHGVPHTLIVDNAGGHLMQHGDVDLVI VGTDRTTANGDVCNKIGTYLKALAARDNGVPFYVALPSPTIDWTVHDGVKEIPIEERPGD EVSFVQGRASDGSIASVRISPEGSPAANPAFDVTPARLITGLITERGIATPSPEGLKALF PERR