Protein Info for SM_b20592 in Sinorhizobium meliloti 1021

Annotation: RNA polymerase sigma factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 227 TIGR02937: RNA polymerase sigma factor, sigma-70 family" amino acids 22 to 187 (166 residues), 99.5 bits, see alignment E=8.2e-33 PF07638: Sigma70_ECF" amino acids 25 to 188 (164 residues), 32.5 bits, see alignment E=1.6e-11 PF04542: Sigma70_r2" amino acids 26 to 92 (67 residues), 58 bits, see alignment E=1.4e-19 PF08281: Sigma70_r4_2" amino acids 132 to 181 (50 residues), 52.6 bits, see alignment E=5.8e-18 PF04545: Sigma70_r4" amino acids 139 to 185 (47 residues), 26 bits, see alignment 1.1e-09

Best Hits

KEGG orthology group: K03088, RNA polymerase sigma-70 factor, ECF subfamily (inferred from 100% identity to sme:SM_b20592)

Predicted SEED Role

"RNA polymerase sigma-70 factor" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92TK7 at UniProt or InterPro

Protein Sequence (227 amino acids)

>SM_b20592 RNA polymerase sigma factor (Sinorhizobium meliloti 1021)
MPTAETDLCLNAPPLAQDLARFRAIMQAHNRKLYRIARSILRNDSDAEDVLQEAYVRAFT
RFEDFRGDAAITTWLARIVINEALGRLRKGRRQMRLAKYMRQSQEAEIIAFPLNSGISDP
EKTMAQRQILDLVERLTDDLPDTYRTVFVLRVIEGLDNEEAAALLGLKPETARTRLHRAR
RILKEQLERQIGPVLLDAFPFAGKRCERLTEAVLARISPRPPEPDGK