Protein Info for SM_b20095 in Sinorhizobium meliloti 1021

Annotation: pyruvate oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02776: TPP_enzyme_N
  • amino acids 3 to 108 (106 residues), 116.5 bits, E=9.1e-38
• PF00205: TPP_enzyme_M
  • amino acids 198 to 327 (130 residues), 110.9 bits, E=6.2e-36
• PF02775: TPP_enzyme_C
  • amino acids 387 to 533 (147 residues), 119.7 bits, E=1.4e-38

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SM_b20095)

Predicted SEED Role

"Pyruvate oxidase [ubiquinone, cytochrome] (EC 1.2.2.2)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.2.2)

MetaCyc Pathways

• pyruvate to cytochrome bo oxidase electron transfer (2/2 steps found)
• pyruvate to cytochrome bd oxidase electron transfer (1/2 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.2.2

Sequence Analysis Tools

See Q92X67 at UniProt or InterPro

Protein Sequence (605 amino acids)

>SM_b20095 pyruvate oxidase (Sinorhizobium meliloti 1021)
MPNTSDILIDTLIEWKFDVVFGLPGDGINGIMEALRRRQDRIRFVSVRHEQSAAFMACAY
AKFTGRLGVCLATSGPGGTNLLTGLYDAKLDQMPVLAITGMQYHDLIETFSQQDVDLTRV
FENVAVYNAQVNDAAHMENLANLACRSALSKRGVAHLSIANDVQERMADGGRSRRNRPGH
MPSRYFAGKLVPLESDLSRAADLLNAGRKVAILAGRGALEAKEALRETAELLGAPVAKAL
LGKAVLPDDDPLTTGGIGILGTAPSQEIMQQCDTLLIIGSTFPYIEYYPRPNTAAGIQID
HDPQRIGLRYPVEVGLVGEAGETLRMLNKRLKRKQDRSFLERAQEQTRNWRRELRAMEGD
RSSPLKPQAAVAAFGRRIAKKGIVVTDSGQNTELAARHLDLGADHMFAVSGALASMASGL
PYAIAAGIAMPDRPVYAVVGDGGFAMQLGEFATAVGYRLPLKLLVIRNDMLNQIAWEQMM
FLGNPQFACELPPIDFAAAAEAMGGRGFTVRSFGELDGIMDQAFAVDGPVVIQALVDRYE
PLMPPKMPADYARNFRAALPETPGHEKIEEILRNSSVGRKVTDEEPQPPHEAAPDENTGE
LPGIP