Protein Info for SGL_RS17055 in Synechocystis sp000284455 PCC 6803

Annotation: UDP-N-acetylmuramate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to MURB_SYNY3: UDP-N-acetylenolpyruvoylglucosamine reductase (murB) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K00075, UDP-N-acetylmuramate dehydrogenase [EC: 1.1.1.158] (inferred from 100% identity to syn:slr1424)

Predicted SEED Role

"UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158)" in subsystem Peptidoglycan Biosynthesis or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 1.1.1.158)

MetaCyc Pathways

peptidoglycan biosynthesis I (meso-diaminopimelate containing) (11/12 steps found)
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) (8/8 steps found)
UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) (7/8 steps found)
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) (6/8 steps found)
peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
peptidoglycan recycling I (9/14 steps found)
peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.158

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (317 amino acids)

>SGL_RS17055 UDP-N-acetylmuramate dehydrogenase (Synechocystis sp000284455 PCC 6803)
MIISPATRPTPMETPAIALAGTGTIIQPETSLAEFTTYRVGGKAEWYAAPRCLEDLVAVL
DWFQGQDLPLTFLGAGSNLLISDQGLAGLVLSTRYLRQSKFDEEQGLITVAAGEPIAKVG
WQAAKRGWQGLEWAVGIPGTVGGAVVMNAGAHNQCTAETLVEATVMRPDGGLEVLTNEQL
GFSYRTSNLQKHLGDRLVVDATFKLTPGFTREEIMGCTTRNLHQRKSTQPYDKPNCGSVF
RNPTPLYSARLIEELGLKGYRIGGAEVSQRHANFIVNIDNAKAQDVFNLIFHVQGEVEKH
YGILLEPEVKMLGEFAR