Protein Info for SGL_RS04920 in Synechocystis sp000284455 PCC 6803

Annotation: tyrosine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 404 TIGR00234: tyrosine--tRNA ligase" amino acids 3 to 402 (400 residues), 457.7 bits, see alignment E=2e-141 PF00579: tRNA-synt_1b" amino acids 38 to 316 (279 residues), 274.7 bits, see alignment E=1.4e-85 PF22421: SYY_C-terminal" amino acids 326 to 400 (75 residues), 31.4 bits, see alignment E=2.2e-11 PF01479: S4" amino acids 342 to 379 (38 residues), 26.9 bits, see alignment 4.8e-10

Best Hits

Swiss-Prot: 100% identical to SYY_SYNY3: Tyrosine--tRNA ligase (tyrS) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K01866, tyrosyl-tRNA synthetase [EC: 6.1.1.1] (inferred from 100% identity to syn:slr1031)

Predicted SEED Role

"Tyrosyl-tRNA synthetase (EC 6.1.1.1)" (EC 6.1.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (404 amino acids)

>SGL_RS04920 tyrosine--tRNA ligase (Synechocystis sp000284455 PCC 6803)
MVVNSDPDWLWRGTAEIFPHNADSNNPQEHLGILTQQDRPLRVKLGIDPTGTDIHLGHSI
PFRKLRAFQDAGHTAVVIIGDFTAQIGDPTGKSEVRKQLTADQVKRNAESYLAQLKPILD
FDTPGRLEIRYNSEWLSNLDLNKILELLATMTVGQMLAKEGFAERFQKENPIFLHEFLYP
LMQGYDSVAVNADVELGGTDQKFNIAVGRDLQRHFGKTPQFGLLLPILLGTDGQQKMSKS
LNNYVGLQEDALSMYSKLEKTPDRLLGEYFELLTNLDLAELPENPRECQKLLAKEVTAQF
HGVAGAIAAQKTAEDIVTQGKAGNTDSVPEFSLAEITFPVKLAYLLSASGLCPSSSEGRR
QIKGGAVRLDGDRLEDVNQEYADPKMLINKVLQMGKKKFIRLIS