Protein Info for SGL_RS02810 in Synechocystis sp000284455 PCC 6803

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 PF00498: FHA" amino acids 29 to 103 (75 residues), 56.2 bits, see alignment E=1.1e-18 PF13188: PAS_8" amino acids 304 to 353 (50 residues), 23.9 bits, see alignment 9.1e-09 TIGR00229: PAS domain S-box protein" amino acids 304 to 407 (104 residues), 29.1 bits, see alignment E=9e-11 PF13426: PAS_9" amino acids 315 to 407 (93 residues), 28.7 bits, see alignment E=3.9e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 422 to 585 (164 residues), 76.9 bits, see alignment E=1.5e-25 PF00990: GGDEF" amino acids 426 to 583 (158 residues), 138.2 bits, see alignment E=6.5e-44 PF00563: EAL" amino acids 604 to 838 (235 residues), 209.8 bits, see alignment E=1.2e-65

Best Hits

KEGG orthology group: None (inferred from 100% identity to syn:slr1102)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (850 amino acids)

>SGL_RS02810 EAL domain-containing protein (Synechocystis sp000284455 PCC 6803)
MSNDSIVRHVLVIEDQKSRRIVSLEENTYDIGRDPSSAIPIYDRQVSRHHATLIRVNDYQ
NHQYTYRLIDGNLQGKRSTNGVVVNGQYCLSHELEHGDVIRFGNQSKASYHIMNLTTESE
EQPYGAEPVSVVANPIMGETYVDPLNFAMADHGYGEGAGFDHEAVEVEEDSSFSTAVVYN
DEIPDVSRSAPLPSHRPPASLSENSTQLIVELTTAGQVIYANGATKALFPELMAIQAQHP
LIQGLSNLSLTREGLQLERDIAIGQQIFHQRIFLGPDRSRLQCYSEDVTEYRKMEQGLND
LHHRLQAYREYSATGFLLVDARTKTVVEANSAFCQLLGYEESEVLDFTLYQLIAAERPVI
EELLINLETQNYLSVPELEYRNREGQTVQVKGEVYRLPWEDREVYCFVMRTPRGRQGYSE
TLANQALYDPISKLPNRVNLQKELSLAIDAAAHHQHLMGVMFIHLEILNRINQAYGFGFG
DEVFMAFHGAISDCMRSGDTVGQWDSNTLVIILAKIKSPQDSIRLAERILDRLKNPITVR
EREFIFNINIGISAYPNDGNRAEDLLSRANAALQKLRQTGFNHYQCYDPKFSTAALHQAR
LENLLQQAIAKRQLTLQYQPQIHLQSGEITAIEALLRWEHPEVGEIAPGKIIPIAARSNL
IFELSDWIFRTACQQNLEWQKDGSPPRAIAINLSAREFYRQDLVMMVGKTLEETGLDPQW
LELEITENTLRQQPAKALAILQDLKTFGVRIALDDFGLGQMGIGFVTQFPFTTIKIHQGF
MARLRGTPQEMAILQSIFALSQGFQYRLVAEGIETDAQLSLIKQLQCQEVQGFLLSRPLR
KREMGQFLQK