Protein Info for Rv3767c in Mycobacterium tuberculosis H37Rv

Annotation: Possible S-adenosylmethionine-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 TIGR00027: methyltransferase, TIGR00027 family" amino acids 17 to 291 (275 residues), 315.3 bits, see alignment E=1.6e-98 PF04072: LCM" amino acids 19 to 204 (186 residues), 225 bits, see alignment E=3.7e-71

Best Hits

Swiss-Prot: 100% identical to Y3793_MYCBO: Putative S-adenosyl-L-methionine-dependent methyltransferase Mb3793c (BQ2027_MB3793C) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mtb:TBMG_03812)

Predicted SEED Role

"O-Methyltransferase involved in polyketide biosynthesis"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (314 amino acids)

>Rv3767c Possible S-adenosylmethionine-dependent methyltransferase (Mycobacterium tuberculosis H37Rv)
VPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARIFVDAAGDGIWSMYTNR
TLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLATADAGVRQVVILASGLDSRAWRL
PWPDGTVVYELDQPKVLEFKSATLRQHGAQPASQLVNVPIDLRQDWPKALQKAGFDPSKP
CAWLAEGLVRYLPARAQDLLFERIDALSRPGSWLASNVPGAGFLDPERMRRQRADMRRMR
AAAAKLVETEISDVDDLWYAEQRTAVAEWLRERGWDVSTATLPELLARYGRSIPHSGEDS
IPPNLFVSAQRATS