Protein Info for Rv3743c in Mycobacterium tuberculosis H37Rv

Annotation: Probable cation transporter P-type ATPase CtpJ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 660 transmembrane" amino acids 31 to 49 (19 residues), see Phobius details amino acids 55 to 77 (23 residues), see Phobius details amino acids 85 to 103 (19 residues), see Phobius details amino acids 108 to 126 (19 residues), see Phobius details amino acids 259 to 277 (19 residues), see Phobius details amino acids 289 to 312 (24 residues), see Phobius details amino acids 599 to 619 (21 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 87 to 645 (559 residues), 548.6 bits, see alignment E=3e-168 TIGR01494: HAD ATPase, P-type, family IC" amino acids 111 to 608 (498 residues), 224.9 bits, see alignment E=2.3e-70 PF00122: E1-E2_ATPase" amino acids 138 to 317 (180 residues), 171.1 bits, see alignment E=1.8e-54 PF00702: Hydrolase" amino acids 337 to 556 (220 residues), 114.3 bits, see alignment E=1e-36

Best Hits

Swiss-Prot: 100% identical to CTPJ_MYCTU: Probable cation-transporting P-type ATPase J (ctpJ) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K01529, [EC: 3.6.1.-] (inferred from 100% identity to mbb:BCG_3802c)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.1.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (660 amino acids)

>Rv3743c Probable cation transporter P-type ATPase CtpJ (Mycobacterium tuberculosis H37Rv)
VAVRELSPARCTSASPLVLARRTKLFALSEMRWAALALGLFSAGLLTQLCGAPQWVRWAL
FLACYATGGWEPGLAGLQALQRRTLDVDLLMVVAAIGAAAIGQIAEGALLIVIFATSGAL
EALVTARTADSVRGLMGLAPGTATRVGAGGGEETVNAADLRIGDIVLVRPGERISADATV
LAGGSEVDQATVTGEPLPVDKSIGDQVFAGTVNGTGALRIRVDRLARDSVVARIATLVEQ
ASQTKARTQLFIEKVEQRYSIGMVAVTLAVFAVPPLWGETLQRALLRAMTFMIVASPCAV
VLATMPPLLAAIANAGRHGVLAKSAIVMEQLGTTTRIAFDKTGTLTRGTPELAGIWVYER
RFTDDELLRLAAAAEYPSEHPLGAAIVKAAQSRRIRLPTVGEFTAHPGCRVTARVDGHVI
AVGSATALLGTAGAAALEASMITAVDFLQGEGYTVVVVVCDSHPVGLLAITDQLRPEAAA
AISAATKLTGAKPVLLTGDNRATADRLGVQVGIDDVRAGLLPDDKVAAVRQLQAGGARLT
VVGDGINDAPALAAAHVGIAMGSARSELTLQTADAVVVRDDLTTIPTVIAMSRRARRIVV
ANLIVAVTFIAGLVVWDLAFTLPLPLGVARHEGSTIIVGLNGLRLLRHTAWRRAAGTAHR