Protein Info for Rv3553 in Mycobacterium tuberculosis H37Rv

Annotation: Possible oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00478: IMPDH
  • amino acids 2 to 205 (204 residues), 38.5 bits, E=1.1e-13
• PF03060: NMO
  • amino acids 5 to 341 (337 residues), 345.5 bits, E=5.6e-107
• PF01070: FMN_dh
  • amino acids 105 to 200 (96 residues), 27 bits, E=3.6e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to mra:MRA_3592)

MetaCyc: 100% identical to 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA dehydrogenase (Mycobacterium tuberculosis H37Rv)
1.3.1.-

Predicted SEED Role

"2-nitropropane dioxygenase (EC 1.13.11.32)" (EC 1.13.11.32)

MetaCyc Pathways

• androstenedione degradation I (aerobic) (22/25 steps found)
• superpathway of cholesterol degradation I (cholesterol oxidase) (34/42 steps found)
• superpathway of cholesterol degradation II (cholesterol dehydrogenase) (36/47 steps found)
• superpathway of testosterone and androsterone degradation (22/28 steps found)
• androstenedione degradation II (anaerobic) (13/27 steps found)
• superpathway of cholesterol degradation III (oxidase) (23/49 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.32

Use Curated BLAST to search for 1.13.11.32

Protein Sequence (355 amino acids)

>Rv3553 Possible oxidoreductase (Mycobacterium tuberculosis H37Rv)
MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASATMTLDELAAAITKV
KAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQLIARLKEAGAVVIPSIG
AAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAVAGTGIPVIAAGGFFDGR
GLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTE
LVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMAANTP
MLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITHLQTASALVE