Protein Info for Rv3371 in Mycobacterium tuberculosis H37Rv

Annotation: Possible triacylglycerol synthase (diacylglycerol acyltransferase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 PF03007: WS_DGAT_cat" amino acids 4 to 237 (234 residues), 143.6 bits, see alignment E=1.1e-45 TIGR02946: acyltransferase, WS/DGAT/MGAT" amino acids 4 to 408 (405 residues), 368.5 bits, see alignment E=2.6e-114 PF06974: WS_DGAT_C" amino acids 272 to 399 (128 residues), 49.7 bits, see alignment E=4.4e-17

Best Hits

Swiss-Prot: 100% identical to Y3371_MYCTU: Putative diacyglycerol O-acyltransferase Rv3371 (Rv3371) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtc:MT3481)

Predicted SEED Role

"Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>Rv3371 Possible triacylglycerol synthase (diacylglycerol acyltransferase) (Mycobacterium tuberculosis H37Rv)
MAQLTALDAGFLKSRDPERHPGLAIGAVAVVNGAAPSYDQLKTVLTERIKSIPRCTQVLA
TEWIDYPGFDLTQHVRRVALPRPGDEAELFRAIALALERPLDPDRPLWECWIIEGLNGNR
WAILIKIHHCMAGAMSAAHLLARLCDDADGSAFANNVDIKQIPPYGDARSWAETLWRMSV
SIAGAVCTAAARAVSWPAVTSPAGPVTTRRRYQAVRVPRDAVDAVCHKFGVTANDVALAA
ITEGFRTVLLHRGQQPRADSLRTLEKTDGSSAMLPYLPVEYDDPVRRLRTVHNRSQQSGR
RQPDSLSDYTPLMLCAKMIHALARLPQQGIVTLATSAPRPRHQLRLMGQKMDQVLPIPPT
ALQLSTGIAVLSYGDELVFGITADYDAASEMQQLVNGIELGVARLVALSDDSVLLFTKDR
RKRSSRALPSAARRGRPSVPTARARH