Protein Info for Rv3234c in Mycobacterium tuberculosis H37Rv

Annotation: Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 271 PF03007: WS_DGAT_cat" amino acids 5 to 270 (266 residues), 298 bits, see alignment E=4.2e-93

Best Hits

Swiss-Prot: 100% identical to TGS3_MYCTU: Probable diacyglycerol O-acyltransferase tgs3 (tgs3) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 99% identity to mtb:TBMG_03282)

Predicted SEED Role

"Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (271 amino acids)

>Rv3234c Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3 (Mycobacterium tuberculosis H37Rv)
VVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLETVEQRLPQIPRYRQKV
QEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELIARLAARPLDKSRPLWEMY
LVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRPPAFPEDIWVPERDPGTTRLL
LRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDIARTVARGTAPSSPLNATV
SRNRRFTVARASLDDYRTVRARYDCDSTTWC