Protein Info for Rv3228 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 TIGR00157: ribosome small subunit-dependent GTPase A" amino acids 71 to 307 (237 residues), 130.7 bits, see alignment E=3.3e-42 PF03193: RsgA_GTPase" amino acids 96 to 267 (172 residues), 148.2 bits, see alignment E=3.3e-47 PF01926: MMR_HSR1" amino acids 201 to 263 (63 residues), 22.2 bits, see alignment E=2e-08

Best Hits

KEGG orthology group: None (inferred from 99% identity to mbb:BCG_3258)

Predicted SEED Role

"Ribosome small subunit-stimulated GTPase EngC" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (330 amino acids)

>Rv3228 Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
LRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAM
RARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANA
DQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVT
AAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTR
SVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPA
DPECALDTLSGPAARRAAAARRLLAVLSQT