Protein Info for Rv3201c in Mycobacterium tuberculosis H37Rv

Annotation: Probable ATP-dependent DNA helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1101 PF00580: UvrD-helicase" amino acids 26 to 337 (312 residues), 156 bits, see alignment E=4.1e-49 PF13245: AAA_19" amino acids 29 to 320 (292 residues), 45.9 bits, see alignment E=1.6e-15 PF13361: UvrD_C" amino acids 395 to 503 (109 residues), 39.2 bits, see alignment E=1.5e-13 amino acids 653 to 770 (118 residues), 64.3 bits, see alignment E=3.5e-21 PF12705: PDDEXK_1" amino acids 903 to 1070 (168 residues), 58.5 bits, see alignment E=2.5e-19

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to mtf:TBFG_13224)

Predicted SEED Role

"ATP-dependent DNA helicase SCO5184"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1101 amino acids)

>Rv3201c Probable ATP-dependent DNA helicase (Mycobacterium tuberculosis H37Rv)
MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGAGAGKTETMAARVVWL
VANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGDPAACAPVVSTYHAFAG
SLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLG
EHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLDALGE
RMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDTGHAQRVVLSSLFGG
GVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSDGTPAPVLELLTSWRNPPQAL
RVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDVQAEREWIADHLRMRYQRAEAD
GVKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPTA
GAAAMRVLTGPRWRLGARDLAALWRRALTLSGESPSTASPESIAMAASADADNPCLADAI
SDPGSAEGYSVAGYGRIGALAGELSALRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSG
GWAGPEHLDAFADVVAGYAERASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRV
QVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAGAHGIPV
LDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDTLLVSGHHWGPTGTKP
RGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARR
GDVERGAALVAAAMSADLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLP
NHLSVSSLVELVGDPVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLP
GAADREVGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGG
ATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTSSVRTAFYYVRSGITVVPDE
LPAPGELAMLLTDCAGRRSDT