Protein Info for Rv3137 in Mycobacterium tuberculosis H37Rv
Annotation: Probable monophosphatase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HISN_MYCTU: Histidinol-phosphatase (hisN) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG orthology group: K01112, [EC: 3.1.3.-] (inferred from 99% identity to mbb:BCG_3160)MetaCyc: 66% identical to histidinol-phosphatase (Corynebacterium glutamicum ATCC 13032)
Histidinol-phosphatase. [EC: 3.1.3.15]
Predicted SEED Role
"Histidinol-phosphatase [alternative form] (EC 3.1.3.15)" in subsystem Histidine Biosynthesis (EC 3.1.3.15)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
- L-histidine biosynthesis (10/10 steps found)
KEGG Metabolic Maps
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Biosynthesis of alkaloids derived from histidine and purine
- Ether lipid metabolism
- Fructose and mannose metabolism
- Histidine metabolism
- Lipopolysaccharide biosynthesis
- Nicotinate and nicotinamide metabolism
- Riboflavin metabolism
- Sphingolipid metabolism
- Thiamine metabolism
Isozymes
Compare fitness of predicted isozymes for: 3.1.3.-, 3.1.3.15
Use Curated BLAST to search for 3.1.3.- or 3.1.3.15
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (260 amino acids)
>Rv3137 Probable monophosphatase (Mycobacterium tuberculosis H37Rv) VSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRP GDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPAL QRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARPGLRERFIGLTDT VWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGG SAVATNGLLHDEVLTRLNAG