Protein Info for Rv3132c in Mycobacterium tuberculosis H37Rv

Annotation: Two component sensor histidine kinase DevS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 578 PF13185: GAF_2" amino acids 62 to 200 (139 residues), 60.1 bits, see alignment E=8.3e-20 amino acids 231 to 369 (139 residues), 38.7 bits, see alignment E=3.5e-13 PF01590: GAF" amino acids 63 to 200 (138 residues), 60.3 bits, see alignment E=9e-20 amino acids 232 to 368 (137 residues), 38.2 bits, see alignment E=5.9e-13 PF13492: GAF_3" amino acids 314 to 368 (55 residues), 32.8 bits, see alignment 2.6e-11 PF07730: HisKA_3" amino acids 387 to 447 (61 residues), 49.7 bits, see alignment E=1.3e-16 PF02518: HATPase_c" amino acids 491 to 576 (86 residues), 47.2 bits, see alignment E=8.2e-16

Best Hits

Swiss-Prot: 100% identical to DEVS_MYCTO: Oxygen sensor histidine kinase response regulator DevS/DosS (devS) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K07682, two-component system, NarL family, sensor histidine kinase DevS [EC: 2.7.13.3] (inferred from 100% identity to mbt:JTY_3150)

Predicted SEED Role

"TWO COMPONENT SENSOR HISTIDINE KINASE DEVS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (578 amino acids)

>Rv3132c Two component sensor histidine kinase DevS (Mycobacterium tuberculosis H37Rv)
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA
GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV
IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP
FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA
AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFV
NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA
FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE
VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG
PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG
SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ