Protein Info for Rv3083 in Mycobacterium tuberculosis H37Rv

Annotation: Probable monooxygenase (hydroxylase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 PF07992: Pyr_redox_2" amino acids 5 to 216 (212 residues), 32.3 bits, see alignment E=2.2e-11 PF13450: NAD_binding_8" amino acids 9 to 62 (54 residues), 30.2 bits, see alignment 1.3e-10 PF00743: FMO-like" amino acids 76 to 349 (274 residues), 50.4 bits, see alignment E=4e-17 PF13434: Lys_Orn_oxgnase" amino acids 94 to 216 (123 residues), 22.8 bits, see alignment E=1.4e-08

Best Hits

Swiss-Prot: 100% identical to MYMA_MYCTO: Putative FAD-containing monooxygenase MymA (mymA) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_3103)

MetaCyc: 100% identical to ethionamide monooxygenase MymA (Mycobacterium tuberculosis H37Rv)
1.14.13.-; 1.14.13.-

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>Rv3083 Probable monooxygenase (hydroxylase) (Mycobacterium tuberculosis H37Rv)
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF
TFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAG
VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV
VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV
PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV
DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV
ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA