Protein Info for Rv3042c in Mycobacterium tuberculosis H37Rv

Annotation: Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 409 PF13740: ACT_6" amino acids 7 to 79 (73 residues), 64.2 bits, see alignment E=2.9e-21 PF21086: ACT_PSP_2" amino acids 94 to 170 (77 residues), 102.9 bits, see alignment E=2.7e-33 TIGR00338: phosphoserine phosphatase SerB" amino acids 167 to 384 (218 residues), 243.3 bits, see alignment E=2.2e-76 PF00702: Hydrolase" amino acids 180 to 353 (174 residues), 91.8 bits, see alignment E=2.8e-29 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 181 to 349 (169 residues), 101 bits, see alignment E=7.5e-33 PF12710: HAD" amino acids 182 to 349 (168 residues), 99.6 bits, see alignment E=1.1e-31 PF08282: Hydrolase_3" amino acids 318 to 374 (57 residues), 43.6 bits, see alignment 1.1e-14

Best Hits

Swiss-Prot: 100% identical to SERB2_MYCTU: Phosphoserine phosphatase SerB2 (serB2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 100% identity to mbt:JTY_3061)

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.3

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (409 amino acids)

>Rv3042c Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase) (Mycobacterium tuberculosis H37Rv)
MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTLGVLVSCPLDVAD
GTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTIFVLGRPITAGAFSAVARGVAAL
GVNIDFIRGISDYPVTGLELRVSVPPGCVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKR
LIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPAT
VIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELEIV
DGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDMLGAAGLGIAFNA
KPALREVADASLSHPYLDTVLFLLGVTRGEIEAADAGDCGVRRVEIPAD