Protein Info for Rv2958c in Mycobacterium tuberculosis H37Rv

Annotation: Possible glycosyl transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 transmembrane" amino acids 138 to 154 (17 residues), see Phobius details amino acids 180 to 200 (21 residues), see Phobius details PF04101: Glyco_tran_28_C" amino acids 269 to 402 (134 residues), 33 bits, see alignment E=9.5e-12 PF00201: UDPGT" amino acids 281 to 406 (126 residues), 40.1 bits, see alignment E=3.3e-14 PF06722: EryCIII-like_C" amino acids 284 to 408 (125 residues), 65.5 bits, see alignment E=7.7e-22

Best Hits

Swiss-Prot: 100% identical to GLTR2_MYCTU: PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c (Rv2958c) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_12972)

MetaCyc: 100% identical to mycoside B rhamnosyltransferase (Mycobacterium tuberculosis H37Rv)
2.4.1.M4 [EC: 2.4.1.M4]; 2.4.1.M4 [EC: 2.4.1.M4]

Predicted SEED Role

"UDP-glucoronosyl and UDP-glucosyltransferases family protein"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.M4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (428 amino acids)

>Rv2958c Possible glycosyl transferase (Mycobacterium tuberculosis H37Rv)
MEETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGEAATLAHVVRPFVLARSLDPSRY
EVHFACDPRFNKLLGPLPFPHHPIHTVPSEEVLLKIAQGRLFYNTRTLRKYIAADRKILN
EIAPDVVVGDNRLSLSVSARLAGIPYIAIANAYWSPQARRRFPLPDVPWTRFFGVRPVSI
LYRLYRPLIFALYCLPLNWLRRKHGLSSLGWDLCRIFTDGDYTLYADVPELVPTYNLPAN
HRYLGPVLWSPDVKPPTWWHSLPTDRPIIYATLGSSGGKNLLQVVLNALADLPVTVIAAT
AGRNHLKNVPANAFVADYLPGEAAAARSAVVLCNGGSPTTQQALAAGVPVIGLPSNMDQH
LNMEALERAGAGVLLRTERLNTEGVAAAVKQVLSGAEFRQAARRLAEAFGPDFAGFPQHI
ESALRLVC