Protein Info for Rv2761c in Mycobacterium tuberculosis H37Rv

Annotation: Possible type I restriction/modification system specificity determinant HsdS (S protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 364 PF01420: Methylase_S" amino acids 5 to 160 (156 residues), 32.5 bits, see alignment E=4.8e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_2771)

Predicted SEED Role

"Type I restriction-modification system, specificity subunit S (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (364 amino acids)

>Rv2761c Possible type I restriction/modification system specificity determinant HsdS (S protein) (Mycobacterium tuberculosis H37Rv)
MSRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANGVIGYSAQHNARGPLIV
VGRVGSYCGSLRYCDSDVWVTDNALACRAKKPEETRYWYYALLGFGLNRYRAGSGQPLLS
QGVLRNVSVSAVAAPDRPRIGEILGAFDDKIAANDRVIEAAEALMLAIVGRLSAYVPLSS
LASRSTACLDAQHFDSTVAHYSFAAFDGGAQPSRVGGRTIRSAKLVVSQPCVLFPKLNPR
IPRIWNITSLPSEMALASTEFVVLRPVGVDTSALWAALRQPDVLAELRQLVGGMTGSRQR
IQPTQLLRVWVRDVRRLTPGHAAAIANLGALCNERRIESARLASCRDALLPLLMSGIDGL
PAGR