Protein Info for Rv2693c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved integral membrane alanine and leucine rich protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 223 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 39 to 59 (21 residues), see Phobius details amino acids 67 to 85 (19 residues), see Phobius details amino acids 91 to 112 (22 residues), see Phobius details amino acids 137 to 158 (22 residues), see Phobius details amino acids 170 to 194 (25 residues), see Phobius details PF11361: DUF3159" amino acids 15 to 200 (186 residues), 232.5 bits, see alignment E=1.8e-73

Best Hits

KEGG orthology group: None (inferred from 100% identity to mtc:MT2767)

Predicted SEED Role

"PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND LEUCINE RICH PROTEIN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (223 amino acids)

>Rv2693c Probable conserved integral membrane alanine and leucine rich protein (Mycobacterium tuberculosis H37Rv)
VNANRTSAQRLLAQAGGVSGLVYSSLPVVTFVVASSAAGLLPAIGFALSMAGLILLWRLL
RRESARPVVAGFCGVAVCALIAYLVGQSKGYFLLGIWMSLLWAVVFTLSILIRRPIVGYL
WSWLSGRDRAWRDVSRAVFAFDVATLGWTLVFAARFIVQRHLYDADKTGWLGVARIGMGW
PLTALAALATYAAIKAAQRAILASHDAAAVGGAAEFDADAGRE