Protein Info for Rv2103c in Mycobacterium tuberculosis H37Rv

Annotation: Possible toxin VapC37. Contains PIN domain.

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 144 transmembrane" amino acids 41 to 48 (8 residues), see Phobius details TIGR00028: toxin-antitoxin system PIN domain toxin" amino acids 1 to 142 (142 residues), 159.1 bits, see alignment E=4.1e-51 PF01850: PIN" amino acids 3 to 133 (131 residues), 57.4 bits, see alignment E=1.1e-19

Best Hits

Swiss-Prot: 100% identical to VPC37_MYCTU: Ribonuclease VapC37 (vapC37) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_2116)

Predicted SEED Role

"Toxin 1, PIN domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (144 amino acids)

>Rv2103c Possible toxin VapC37. Contains PIN domain. (Mycobacterium tuberculosis H37Rv)
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRP
LPREAAITQVADWLAAPSAVLVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRA
SIVSYDSDFGRFEGVRWDQPPALL