Protein Info for Rv2048c in Mycobacterium tuberculosis H37Rv

Annotation: Polyketide synthase Pks12

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3000 3500 4151 transmembrane" amino acids 1465 to 1485 (21 residues), see Phobius details amino acids 1499 to 1512 (14 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 35 to 281 (247 residues), 308.9 bits, see alignment 3.1e-95 amino acids 2057 to 2304 (248 residues), 319.2 bits, see alignment 2.3e-98 PF02801: Ketoacyl-synt_C" amino acids 289 to 407 (119 residues), 144.8 bits, see alignment (E = 1.3e-45) amino acids 2312 to 2430 (119 residues), 144.8 bits, see alignment (E = 1.3e-45) PF16197: KAsynt_C_assoc" amino acids 410 to 524 (115 residues), 46 bits, see alignment (E = 6.7e-15) amino acids 2433 to 2547 (115 residues), 46 bits, see alignment (E = 6.7e-15) PF22336: RhiE-like_linker" amino acids 476 to 539 (64 residues), 28.7 bits, see alignment (E = 1.1e-09) amino acids 2499 to 2562 (64 residues), 28.7 bits, see alignment (E = 1.1e-09) PF22621: CurL-like_PKS_C" amino acids 476 to 533 (58 residues), 36 bits, see alignment (E = 5.7e-12) amino acids 2499 to 2556 (58 residues), 36 bits, see alignment (E = 5.7e-12) PF00698: Acyl_transf_1" amino acids 559 to 880 (322 residues), 318 bits, see alignment 8.7e-98 amino acids 2582 to 2894 (313 residues), 213.3 bits, see alignment 6.7e-66 PF21089: PKS_DH_N" amino acids 926 to 1026 (101 residues), 96.4 bits, see alignment (E = 9.6e-31) amino acids 2940 to 3040 (101 residues), 90.9 bits, see alignment (E = 4.8e-29) PF14765: PS-DH" amino acids 1050 to 1194 (145 residues), 78.4 bits, see alignment (E = 4.9e-25) amino acids 3063 to 3215 (153 residues), 87.5 bits, see alignment (E = 7.8e-28) PF22953: SpnB_Rossmann" amino acids 1239 to 1340 (102 residues), 59.6 bits, see alignment (E = 5.1e-19) amino acids 3245 to 3369 (125 residues), 63.2 bits, see alignment (E = 3.8e-20) PF08240: ADH_N" amino acids 1384 to 1440 (57 residues), 37.8 bits, see alignment (E = 2e-12) amino acids 3413 to 3477 (65 residues), 33.7 bits, see alignment (E = 3.8e-11) PF00107: ADH_zinc_N" amino acids 1504 to 1593 (90 residues), 52.8 bits, see alignment (E = 4.1e-17) amino acids 3534 to 3623 (90 residues), 52.8 bits, see alignment (E = 4.1e-17) PF13602: ADH_zinc_N_2" amino acids 1540 to 1670 (131 residues), 77 bits, see alignment (E = 3e-24) amino acids 3570 to 3700 (131 residues), 79.6 bits, see alignment (E = 4.7e-25) PF08659: KR" amino acids 1680 to 1858 (179 residues), 202.3 bits, see alignment (E = 6.7e-63) amino acids 3710 to 3888 (179 residues), 202.3 bits, see alignment (E = 6.7e-63) PF00106: adh_short" amino acids 1681 to 1839 (159 residues), 36.9 bits, see alignment (E = 2.8e-12) amino acids 3711 to 3869 (159 residues), 37 bits, see alignment (E = 2.6e-12) PF01370: Epimerase" amino acids 1682 to 1822 (141 residues), 30.4 bits, see alignment (E = 2.9e-10) amino acids 3712 to 3852 (141 residues), 30.4 bits, see alignment (E = 2.9e-10) PF00550: PP-binding" amino acids 1971 to 2034 (64 residues), 53.2 bits, see alignment (E = 3.2e-17) amino acids 4000 to 4065 (66 residues), 48.8 bits, see alignment (E = 7.2e-16)

Best Hits

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (4151 amino acids)

>Rv2048c Polyketide synthase Pks12 (Mycobacterium tuberculosis H37Rv)
MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMV
ADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALA
MDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLAEEIEGYRLTGMTSS
VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV
EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD
GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD
RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA
VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAK
SESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAG
DQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDW
SLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVA
GALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAV
VVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVF
FSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEET
FAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAGYVELPTYAF
DKRRFWLSAEGSGADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAV
SDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRG
VSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGYRYG
PAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELALPFA
WQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLAAVSG
SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDH
ESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMA
LATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNAD
APLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVF
GFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHA
GTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGG
RGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPG
RPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAG
TVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVAC
DAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHE
LTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQA
SAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAV
PPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNI
TPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG
LPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDL
AGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALER
AGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAV
SVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAF
AAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRV
VRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNM
GHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTR
RAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVR
GDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGK
TVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNST
EFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRL
MQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNAVAAVADQLRADGR
RVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQLAGDDFGSAAYWRR
HIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSALRKDRPEPAT
LTNAVAQGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAAGLGLAASEH
ALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDEVGCGV
VDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGALRAGSA
EPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADA
GVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAP
VGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVE
PLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRG
AVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWR
RGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVA
VSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTV
ASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAV
QLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSL
AGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAE
LATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGSWAAGTVLITGGTGM
AGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAK
VIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAF
VMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATV
DFKRFARDGIVAMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLI
NAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPD
RAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSA
VAAGEAELQRIVASIPVKRLRQAGVLDLLLALANETETSGQDPALAPTAEQEIADMDLDD
LVNAAFRNDDE