Protein Info for Rv2003c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 154 to 169 (16 residues), see Phobius details PF08241: Methyltransf_11" amino acids 102 to 187 (86 residues), 43.8 bits, see alignment E=5.1e-15 PF13489: Methyltransf_23" amino acids 102 to 234 (133 residues), 35.2 bits, see alignment E=1.5e-12 PF13649: Methyltransf_25" amino acids 102 to 183 (82 residues), 34.3 bits, see alignment E=4.9e-12

Best Hits

Swiss-Prot: 100% identical to Y2003_MYCTU: Uncharacterized protein Rv2003c (Rv2003c) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbb:BCG_2020c)

Predicted SEED Role

"FIG147732: hypothetical protein Rv2003c/MT2059"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>Rv2003c Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
VVKRSRATRLSPSIWSGWESPQCRSIRARLLLPRGRSRPPNADCCWNQLAVTPDTRMPAS
SAAGRDAAAYDAWYDSPTGRPILATEVAALRPLIEVFAQPRLEIGVGTGRFADLLGVRFG
LDPSRDALMFARRRGVLVANAVGEAVPFVSRHFGAVLMAFTLCFVTDPAAIFRETRRLLA
DGGGLVIGFLPRGTPWADLYALRAARGQPGYRDARFYTAAELEQLLADSGFRVIARRCTL
HQPPGLARYDIEAAHDGIQAGAGFVAISAVDQAHEPKDDHPLESE