Protein Info for Rv1945 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 PF02720: DUF222" amino acids 38 to 361 (324 residues), 371.1 bits, see alignment E=4.6e-115 PF01844: HNH" amino acids 364 to 404 (41 residues), 22.5 bits, see alignment 1e-08

Best Hits

Swiss-Prot: 100% identical to Y1945_MYCTU: Uncharacterized protein Rv1945 (Rv1945) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbo:Mb1980)

Predicted SEED Role

"Partial REP13E12 repeat protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>Rv1945 Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQ
LAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAA
QREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWL
HPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQ
TPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKEL
EAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAK
DRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDT
EWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH