Protein Info for Rv1661 in Mycobacterium tuberculosis H37Rv

Annotation: Probable polyketide synthase Pks7

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2126 transmembrane" amino acids 1472 to 1492 (21 residues), see Phobius details amino acids 1504 to 1524 (21 residues), see Phobius details PF08990: Docking" amino acids 4 to 31 (28 residues), 28 bits, see alignment (E = 1.4e-09) PF00109: ketoacyl-synt" amino acids 35 to 284 (250 residues), 320.2 bits, see alignment E=9.9e-99 PF02801: Ketoacyl-synt_C" amino acids 292 to 408 (117 residues), 142.9 bits, see alignment 4.5e-45 PF16197: KAsynt_C_assoc" amino acids 411 to 528 (118 residues), 54.4 bits, see alignment 1.5e-17 PF22621: CurL-like_PKS_C" amino acids 479 to 539 (61 residues), 32.7 bits, see alignment (E = 5.7e-11) PF00698: Acyl_transf_1" amino acids 564 to 884 (321 residues), 327.6 bits, see alignment E=9.9e-101 PF21089: PKS_DH_N" amino acids 934 to 1032 (99 residues), 85.9 bits, see alignment 1.6e-27 PF14765: PS-DH" amino acids 1060 to 1204 (145 residues), 86.4 bits, see alignment 1.6e-27 PF22953: SpnB_Rossmann" amino acids 1231 to 1352 (122 residues), 119.5 bits, see alignment 1.8e-37 PF08240: ADH_N" amino acids 1395 to 1449 (55 residues), 36 bits, see alignment (E = 7e-12) PF00107: ADH_zinc_N" amino acids 1512 to 1601 (90 residues), 45.1 bits, see alignment (E = 9.2e-15) PF13602: ADH_zinc_N_2" amino acids 1549 to 1679 (131 residues), 69 bits, see alignment 7.5e-22 PF08659: KR" amino acids 1694 to 1872 (179 residues), 200.2 bits, see alignment E=2.6e-62 PF00106: adh_short" amino acids 1695 to 1853 (159 residues), 43.9 bits, see alignment 1.9e-14 PF01370: Epimerase" amino acids 1696 to 1839 (144 residues), 33.9 bits, see alignment 2.1e-11 PF00550: PP-binding" amino acids 1982 to 2047 (66 residues), 49.6 bits, see alignment (E = 3.6e-16)

Best Hits

Predicted SEED Role

"Probable polyketide synthase pks7"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2126 amino acids)

>Rv1661 Probable polyketide synthase Pks7 (Mycobacterium tuberculosis H37Rv)
MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV
AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA
MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS
TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA
MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV
NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY
GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG
AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL
SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT
GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE
HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA
AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG
VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS
TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG
IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV
ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA
PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV
EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ
VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG
EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA
AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV
LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD
GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA
DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT
GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA
GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE
AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR
AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT
IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA
LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT
VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG
LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA
RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD
LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP
ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS
LTTEDDDIAAATESQLFAILDEELGS