Protein Info for Rv1442 in Mycobacterium tuberculosis H37Rv

Annotation: Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 766 PF18364: Molybdopterin_N" amino acids 6 to 46 (41 residues), 46.9 bits, see alignment 3.3e-16 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 7 to 764 (758 residues), 1145.3 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 50 to 510 (461 residues), 147.3 bits, see alignment E=9.4e-47 PF01568: Molydop_binding" amino acids 623 to 739 (117 residues), 79.1 bits, see alignment E=3.7e-26

Best Hits

KEGG orthology group: K07812, trimethylamine-N-oxide reductase (cytochrome c) 2 [EC: 1.7.2.3] (inferred from 100% identity to mtc:MT1487)

Predicted SEED Role

"Anaerobic dimethyl sulfoxide reductase chain A (EC 1.8.5.3)" (EC 1.8.5.3)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.2.3 or 1.8.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (766 amino acids)

>Rv1442 Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase) (Mycobacterium tuberculosis H37Rv)
MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGW
LQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSSYGWASAGRFHHA
QSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVA
FGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLRDDIAAIAGPLDDRCRWLA
PVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALS
GLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQIGLPGGGFGHG
YSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCV
YWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFERDDFAASK
TNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYDKWSAELD
FPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDC
AGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLHSQLDHGGASMASKIRGREPIRIHPD
DAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHG
NPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA