Protein Info for Rv1355c in Mycobacterium tuberculosis H37Rv

Annotation: Possible molybdopterin biosynthesis protein MoeY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 715 PF00899: ThiF" amino acids 91 to 228 (138 residues), 83.6 bits, see alignment E=1.2e-27

Best Hits

Swiss-Prot: 100% identical to Y1355_MYCTO: Uncharacterized protein MT1398 (MT1398) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mbb:BCG_1417c)

Predicted SEED Role

"POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (715 amino acids)

>Rv1355c Possible molybdopterin biosynthesis protein MoeY (Mycobacterium tuberculosis H37Rv)
VTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQLAGVRRLLPQPDPDLL
EEAKRWAYYPWRRMVVAILGLRGFRAVRLDRNRHLITAEEQRALHALRVGVVGLSAGHAI
AYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNKAMIAARRIAELDPYLAVDLV
TSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACARGVPVLMATSDRGLVDVERYDV
EPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILDCQELSARCAASMIEVDQTLWGWPQ
LAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDRLDQPPMPSRGNGWLLESVPP
TAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVVAKQHSLTIRLAPEHTSAMDIAFRGSAVA
VGAAMFNARVAAAAHRVLGSVEFDESQPDSPLQATMHFGRGDDPSLAALYRPMLLRTTNR
HHGMPGHVHPATVELLTNTAAAEGARLQLLLSRNEIDRAATILAAADRIRYLTPRLHEEM
MSELRWPGDPSLDAGIDVRSLELDSGELRVLDILRRSDVVARLAQWDCGTALEDNTNERV
SASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQHGLAVQPMSPIFLYARGRHDLDQAS
PHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFHAPPPSVCSRRRVRHAIPEPHR