Protein Info for Rv1282c in Mycobacterium tuberculosis H37Rv

Annotation: Probable oligopeptide-transport integral membrane protein ABC transporter OppC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details transmembrane" amino acids 85 to 109 (25 residues), see Phobius details amino acids 117 to 137 (21 residues), see Phobius details amino acids 143 to 163 (21 residues), see Phobius details amino acids 196 to 218 (23 residues), see Phobius details amino acids 249 to 270 (22 residues), see Phobius details PF12911: OppC_N" amino acids 10 to 58 (49 residues), 42.1 bits, see alignment 6.3e-15 PF00528: BPD_transp_1" amino acids 101 to 283 (183 residues), 89.2 bits, see alignment E=2.8e-29

Best Hits

Swiss-Prot: 100% identical to Y1282_MYCTO: Putative peptide transport permease protein MT1319 (MT1319) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K02034, peptide/nickel transport system permease protein (inferred from 100% identity to mtb:TBMG_02699)

MetaCyc: 34% identical to glutathione ABC transporter membrane subunit GsiD (Escherichia coli K-12 substr. MG1655)
RXN0-11 [EC: 7.4.2.10]

Predicted SEED Role

"Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1)" in subsystem ABC transporter oligopeptide (TC 3.A.1.5.1) (TC 3.A.1.5.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>Rv1282c Probable oligopeptide-transport integral membrane protein ABC transporter OppC (Mycobacterium tuberculosis H37Rv)
MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYSYDDLDFNALLQPPGT
KHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGAISGYFGGWRDRTLMWV
VDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSRMVRGMTMSLREREFIRA
ARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGLSFLGFGIQPPDVSLGTLI
ADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDPASRSLRRGVR