Protein Info for Rv1266c in Mycobacterium tuberculosis H37Rv

Annotation: Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 transmembrane" amino acids 402 to 426 (25 residues), see Phobius details PF00069: Pkinase" amino acids 16 to 230 (215 residues), 153.8 bits, see alignment E=1.3e-48 PF07714: PK_Tyr_Ser-Thr" amino acids 17 to 261 (245 residues), 107.2 bits, see alignment E=1.9e-34 PF14032: PknH_C" amino acids 437 to 622 (186 residues), 211.4 bits, see alignment E=2.1e-66

Best Hits

Swiss-Prot: 100% identical to PKNH_MYCTU: Serine/threonine-protein kinase PknH (pknH) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K08884, serine/threonine protein kinase, bacterial [EC: 2.7.11.1] (inferred from 100% identity to mtu:Rv1266c)

Predicted SEED Role

"Serine/threonine protein kinase (EC 2.7.11.1)" (EC 2.7.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (626 amino acids)

>Rv1266c Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H) (Mycobacterium tuberculosis H37Rv)
MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAEFSKDPVFRER
MKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAII
TQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWK
YMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRP
GIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAGQRPGPTGQPSWAPN
SGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPLVAGAAAVVLVLVLGAI
GIWIAIRPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDSSPVTVSLP
DCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFPTADKARAFVQTSAD
KWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVD
VNACGYRITNQAGQIAAKIVDKVNKE