Protein Info for Rv0800 in Mycobacterium tuberculosis H37Rv

Annotation: Probable aminopeptidase PepC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 PF02127: Peptidase_M18" amino acids 11 to 425 (415 residues), 482.3 bits, see alignment E=7.1e-149

Best Hits

Swiss-Prot: 100% identical to APEB_MYCTA: Probable M18 family aminopeptidase 2 (apeB) from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)

KEGG orthology group: K01269, aminopeptidase [EC: 3.4.11.-] (inferred from 100% identity to mbo:Mb0823)

Predicted SEED Role

"Aspartyl aminopeptidase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (433 amino acids)

>Rv0800 Probable aminopeptidase PepC (Mycobacterium tuberculosis H37Rv)
MAATAHGLCEFIDASPSPFHVCATVAGRLLGAGYRELREADRWPDKPGRYFTVRAGSLVA
WNAEQSGHTQVPFRIVGAHTDSPNLRVKQHPDRLVAGWHVVALQPYGGVWLHSWLDRDLG
ISGRLSVRDGTGVSHRLVLIDDPILRVPQLAIHLAEDRKSLTLDPQRHINAVWGVGERVE
SFVGYVAQRAGVAAADVLAADLMTHDLTPSALIGASVNGTASLLSAPRLDNQASCYAGME
ALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQSDLLSSVLERIVLAAGGTREDFLRR
LTTSMLASADMAHATHPNYPDRHEPSHPIEVNAGPVLKVHPNLRYATDGRTAAAFALACQ
RAGVPMQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQLAMHSARELMGAHDVAAYSA
ALQAFLSAELSEA