Protein Info for Rv0657c in Mycobacterium tuberculosis H37Rv

Annotation: Possible antitoxin VapB6

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 51 PF09957: VapB_antitoxin" amino acids 3 to 45 (43 residues), 63.6 bits, see alignment E=6.1e-22

Best Hits

Swiss-Prot: 98% identical to VAPB6_MYCTO: Putative antitoxin VapB6 (vapB6) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 98% identity to mra:MRA_0667A)

Predicted SEED Role

"VapB6 protein (antitoxin to VapC6)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (51 amino acids)

>Rv0657c Possible antitoxin VapB6 (Mycobacterium tuberculosis H37Rv)
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE