Protein Info for Rv0648 in Mycobacterium tuberculosis H37Rv

Annotation: Alpha-mannosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1215 PF01074: Glyco_hydro_38N" amino acids 1 to 211 (211 residues), 126.4 bits, see alignment E=3e-40 PF09261: Alpha-mann_mid" amino acids 216 to 304 (89 residues), 51.3 bits, see alignment 2.1e-17 PF10633: NPCBM_assoc" amino acids 1008 to 1082 (75 residues), 70 bits, see alignment 3.1e-23

Best Hits

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_10661)

Predicted SEED Role

"Alpha-mannosidase (EC 3.2.1.24)" in subsystem Fructooligosaccharides(FOS) and Raffinose Utilization or Mannose Metabolism (EC 3.2.1.24)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.1.24

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1215 amino acids)

>Rv0648 Alpha-mannosidase (Mycobacterium tuberculosis H37Rv)
VMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADA
GLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTHYMPAHYSAGWSMDSST
SLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWVTAIHRDWGARYTWPRFVCAL
PKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYIDTKQANRAAENAVLEAERFAVF
AALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNS
LRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVEHDGR
SVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVDPERGGALSSLVQDG
RQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPVVCSSACPAQVQAYRGPLGQRLV
VRGRIGTLLRYTQTLTLWDGVDRVDCRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDA
VVGRGFALLHEGPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTE
TVSGPMARDLMVALVRAGVTATCSGADKPRYGHLDVDSNLPDARIALGGPDRNTFTKAVL
AEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGADLRAPCALPVLVIDGRDEKHL
RAAVASLADDLADAEIVVHQRAAPQMEPFEDRTVALLNRGVPSFAVDSEGTLHTALMRSC
TGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLA
VAPRRPQGELPAVGSLLHVEPADSVQLGALKAAGNPLAAGSARPVQPAAVALRLVQTTGA
DTPVTIGCELGKVGALRPADLLETPLAMARARKSSIDLHGYQVATVLARLDVAADMANVL
AADDVALAPHAETAQPQYARYWLHNRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAA
SDCTDSVLGGVVDVVCPLGWPATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQL
RVVDTAVPAAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGSRA
HAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGC
AGQLVYSPAVKVSVT