Protein Info for Rv0574c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 380 PF09587: PGA_cap" amino acids 9 to 291 (283 residues), 258.7 bits, see alignment E=3e-81

Best Hits

Swiss-Prot: 100% identical to Y0574_MYCTO: Probable polyglutamine synthesis accessory protein MT0602 (MT0602) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K07282, poly-gamma-glutamate synthesis protein (capsule biosynthesis protein) (inferred from 100% identity to mbb:BCG_0619c)

Predicted SEED Role

"Capsule biosynthesis protein CapA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (380 amino acids)

>Rv0574c Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
VAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPV
DWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHV
CALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVA
AESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGY
ATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESF
RSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRV
VTRPDNLLEVVPAANLTSKE