Protein Info for Rv0507 in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 968 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 219 to 239 (21 residues), see Phobius details amino acids 248 to 272 (25 residues), see Phobius details amino acids 293 to 317 (25 residues), see Phobius details amino acids 329 to 354 (26 residues), see Phobius details amino acids 375 to 398 (24 residues), see Phobius details amino acids 763 to 783 (21 residues), see Phobius details amino acids 788 to 812 (25 residues), see Phobius details amino acids 820 to 842 (23 residues), see Phobius details amino acids 862 to 886 (25 residues), see Phobius details amino acids 898 to 927 (30 residues), see Phobius details TIGR00833: transport protein" amino acids 21 to 929 (909 residues), 982.6 bits, see alignment E=1.2e-299 PF03176: MMPL" amino acids 54 to 382 (329 residues), 400.2 bits, see alignment E=3.2e-124 amino acids 602 to 938 (337 residues), 358.2 bits, see alignment E=1.9e-111

Best Hits

Swiss-Prot: 100% identical to MMPL2_MYCTU: Probable transport protein MmpL2 (mmpL2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mbo:Mb0519)

Predicted SEED Role

"membrane protein, MmpL family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (968 amino acids)

>Rv0507 Probable conserved transmembrane transport protein MmpL2 (Mycobacterium tuberculosis H37Rv)
MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDA
ASIQAIKRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDF
WGDPLTAAGSQSADDRAAYVVVYLVGNNETEAYDSVHAVRHMVDTTPPPHGVKAYVTGPA
ALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLIMVGIDLGAIRGFIALL
ADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYHESRYAGEDRETAFYTMFHGTAHVI
LGSGLTIAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTVGSFFKLFDPK
RRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGD
AAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAITRPLGTT
IKHTSIPFIISMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTV
DMDHLTHDMSDITATLRDHLADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVD
QLSEKLEYLVKDMDILITLLPQMRAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNK
DPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEG
ISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAISLILIIM
MIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYN
LLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIG
LGLLFDTLVVRSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQH
PSATGAHE