Protein Info for Rv0402c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 958 transmembrane" amino acids 19 to 39 (21 residues), see Phobius details amino acids 193 to 212 (20 residues), see Phobius details amino acids 219 to 240 (22 residues), see Phobius details amino acids 250 to 273 (24 residues), see Phobius details amino acids 287 to 311 (25 residues), see Phobius details amino acids 329 to 353 (25 residues), see Phobius details amino acids 374 to 396 (23 residues), see Phobius details amino acids 761 to 781 (21 residues), see Phobius details amino acids 789 to 812 (24 residues), see Phobius details amino acids 821 to 843 (23 residues), see Phobius details amino acids 864 to 885 (22 residues), see Phobius details amino acids 897 to 924 (28 residues), see Phobius details TIGR00833: transport protein" amino acids 21 to 928 (908 residues), 998.7 bits, see alignment E=1.6e-304 PF03176: MMPL" amino acids 53 to 381 (329 residues), 403.4 bits, see alignment E=3.4e-125 amino acids 601 to 940 (340 residues), 345.9 bits, see alignment E=1.1e-107

Best Hits

Swiss-Prot: 100% identical to MMPL1_MYCTU: Probable transport protein MmpL1 (mmpL1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mtf:TBFG_10407)

Predicted SEED Role

"Transmembrane transport protein MmpL1"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (958 amino acids)

>Rv0402c Probable conserved transmembrane transport protein MmpL1 (Mycobacterium tuberculosis H37Rv)
VRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPS
LIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTKLSQDTTHVQHIENFWG
DPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGP
LGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFA
VNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVL
ASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKR
ATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIGYL
ASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPI
DHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHD
MNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDK
LTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRN
ATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGI
SHIDPIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIML
GITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNL
LLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMI
GLLFDTLVVRSYMTPALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ