Protein Info for Rv0355c in Mycobacterium tuberculosis H37Rv

Annotation: PPE family protein PPE8

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3000 3300 PF00823: PPE" amino acids 3 to 166 (164 residues), 205.1 bits, see alignment 7.6e-65 PF01469: Pentapeptide_2" amino acids 196 to 229 (34 residues), 26.5 bits, see alignment (E = 5e-10) amino acids 210 to 245 (36 residues), 27.3 bits, see alignment (E = 2.8e-10) amino acids 335 to 373 (39 residues), 39.3 bits, see alignment (E = 4.8e-14) amino acids 375 to 413 (39 residues), 32.2 bits, see alignment (E = 8.2e-12) amino acids 571 to 611 (41 residues), 27.1 bits, see alignment (E = 3e-10) amino acids 604 to 640 (37 residues), 28.9 bits, see alignment (E = 8.4e-11) amino acids 628 to 665 (38 residues), 27.8 bits, see alignment (E = 1.9e-10) amino acids 702 to 740 (39 residues), 35.3 bits, see alignment (E = 8.4e-13) amino acids 733 to 770 (38 residues), 38.6 bits, see alignment (E = 8.2e-14) amino acids 743 to 780 (38 residues), 38.6 bits, see alignment (E = 8.2e-14) amino acids 772 to 810 (39 residues), 31.6 bits, see alignment (E = 1.2e-11) amino acids 1020 to 1053 (34 residues), 32 bits, see alignment (E = 9.4e-12) amino acids 1056 to 1094 (39 residues), 29.7 bits, see alignment (E = 5e-11) amino acids 1082 to 1119 (38 residues), 28.2 bits, see alignment (E = 1.4e-10) amino acids 1166 to 1204 (39 residues), 40.6 bits, see alignment (E = 1.9e-14) amino acids 1206 to 1244 (39 residues), 37.8 bits, see alignment (E = 1.4e-13) amino acids 1469 to 1504 (36 residues), 31.3 bits, see alignment (E = 1.6e-11) amino acids 1515 to 1553 (39 residues), 30.3 bits, see alignment (E = 3e-11) amino acids 1541 to 1578 (38 residues), 29.1 bits, see alignment (E = 7.4e-11) amino acids 1588 to 1623 (36 residues), 26.5 bits, see alignment (E = 4.7e-10) amino acids 1615 to 1654 (40 residues), 35.5 bits, see alignment (E = 7.3e-13) amino acids 1646 to 1684 (39 residues), 34.6 bits, see alignment (E = 1.4e-12) amino acids 1676 to 1714 (39 residues), 33.1 bits, see alignment (E = 4.3e-12) amino acids 1940 to 1978 (39 residues), 27.3 bits, see alignment (E = 2.8e-10) amino acids 2010 to 2047 (38 residues), 30.7 bits, see alignment (E = 2.4e-11) amino acids 2053 to 2089 (37 residues), 32.2 bits, see alignment (E = 7.8e-12) amino acids 2081 to 2119 (39 residues), 27.9 bits, see alignment (E = 1.7e-10) amino acids 2091 to 2129 (39 residues), 27.3 bits, see alignment (E = 2.7e-10) amino acids 2101 to 2140 (40 residues), 35.2 bits, see alignment (E = 9e-13) amino acids 2121 to 2160 (40 residues), 36.2 bits, see alignment (E = 4.6e-13) amino acids 2132 to 2169 (38 residues), 38 bits, see alignment (E = 1.2e-13) amino acids 2161 to 2199 (39 residues), 36.3 bits, see alignment (E = 4.3e-13) amino acids 2422 to 2457 (36 residues), 32.2 bits, see alignment (E = 8.1e-12) amino acids 2448 to 2486 (39 residues), 30.5 bits, see alignment (E = 2.7e-11) amino acids 2538 to 2575 (38 residues), 28.2 bits, see alignment (E = 1.4e-10) amino acids 2601 to 2636 (36 residues), 33.2 bits, see alignment (E = 4e-12) amino acids 2618 to 2656 (39 residues), 27.3 bits, see alignment (E = 2.7e-10) amino acids 2662 to 2698 (37 residues), 27.3 bits, see alignment (E = 2.7e-10) amino acids 2700 to 2738 (39 residues), 33.7 bits, see alignment (E = 2.7e-12) amino acids 2741 to 2779 (39 residues), 37.1 bits, see alignment (E = 2.4e-13) amino acids 3018 to 3052 (35 residues), 33.4 bits, see alignment (E = 3.4e-12) amino acids 3053 to 3088 (36 residues), 38 bits, see alignment (E = 1.2e-13) amino acids 3094 to 3132 (39 residues), 27.6 bits, see alignment (E = 2.1e-10) amino acids 3137 to 3174 (38 residues), 27.6 bits, see alignment (E = 2.3e-10) amino acids 3166 to 3204 (39 residues), 28.8 bits, see alignment (E = 9e-11) amino acids 3177 to 3215 (39 residues), 36.4 bits, see alignment (E = 4e-13) amino acids 3197 to 3235 (39 residues), 39.5 bits, see alignment (E = 4.1e-14) amino acids 3237 to 3274 (38 residues), 29.1 bits, see alignment (E = 7.5e-11)

Best Hits

Predicted SEED Role

"PPE family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (3300 amino acids)

>Rv0355c PPE family protein PPE8 (Mycobacterium tuberculosis H37Rv)
MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAASFSAVTAGLAGSSWLGA
ASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALAATVHPAIISANRALFVSL
VVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASAAVSALTPFGQALPTVAGGGA
LVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLGSANIGNGNIGSGNIGSSNIGFG
NVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFGNTGDGNRGIGLTGSGLLGFGGLNS
GTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSYNTGFGNSGDANTGFFNSGIANTGVGN
AGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSGNYNTGLANSGNVNTGAFITGNFNNGFLW
RGDHQGLIFGSPGFFNSTSAPSSGFFNSGAGSASGFLNSGANNSGFFNSSSGAIGNSGLA
NAGVLVSGVINSGNTVSGLFNMSLVAITTPALISGFFNTGSNMSGFFGGPPVFNLGLANR
GVVNILGNANIGNYNILGSGNVGDFNILGSGNLGSQNILGSGNVGSFNIGSGNIGVFNVG
SGSLGNYNIGSGNLGIYNIGFGNVGDYNVGFGNAGDFNQGFANTGNNNIGFANTGNNNIG
IGLSGDNQQGFNIASGWNSGTGNSGLFNSGTNNVGIFNAGTGNVGIANSGTGNWGIGNPG
TDNTGILNAGSYNTGILNAGDFNTGFYNTGSYNTGGFNVGNTNTGNFNVGDTNTGSYNPG
DTNTGFFNPGNVNTGAFDTGDFNNGFLVAGDNQGQIAIDLSVTTPFIPINEQMVIDVHNV
MTFGGNMITVTEASTVFPQTFYLSGLFFFGPVNLSASTLTVPTITLTIGGPTVTVPISIV
GALESRTITFLKIDPAPGIGNSTTNPSSGFFNSGTGGTSGFQNVGGGSSGVWNSGLSSAI
GNSGFQNLGSLQSGWANLGNSVSGFFNTSTVNLSTPANVSGLNNIGTNLSGVFRGPTGTI
FNAGLANLGQLNIGSANLGDFNLGSGNVGSFNVFSGNQGSYNIGPANLGNYNIGFANLGN
YNIGFGNAGDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGL
FNSGTNNVGIGNSGTGNWGIGNSGSGNTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGW
YNTGDTNTGIANLGDFNTGFYNTGNFSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLF
SAGYRVHVPEIPAHVTVEVPVNIPITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAI
SKAVLPPITGTGPAITVNIGDPGGSTAIRIPATASVGPFDVTFVNIAATTGFFNATTDPS
SGFFNGGPGTVSGIANIGANISGFQNVANSATSGFNNYGSLQSGLANLGDTVSGVFNTGI
GAPANVSGMFNIGSNLAGFFHDQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGLANIGSF
NLGSGNLGSFNVFGGNQGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANTGNN
NIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGSGNSGLFNSGTNNIGLFNSGTGNIGIG
NSGTGNWGIANTGDTNTGIFNTGDVNTGLLNAGNVNTGIFNTGHYNTGSFNAGSFNTAGF
NPGSYNTGYLNTGSYNTGLANSGDVNTGGFITGNYSNGFWWRGDYQGLAGISQTITVPDT
AVPVKLHVPIFLDIPVTGTLGTFTVHGFRFPEITGDIFLIGIPFNAATLDAFSFPNISIV
LPNIGINLGSGPDPLIDIAGTGGLLPIKIPLIDIPAAPGFGNSTTTPSSGFFNAGTGTVS
GVGNVGSNSSGFFNLTSGSSGISGVQNFGELISGGFNFGNTVSGLVNASTLGLSMPANLS
GGGNVGATVAGFVNNTQILNLGFGNVGSGNVGHGNIGDSNVGLGNLGNANVGHGNIGSFN
VFSGNRGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANSGSNNIGFANTGNNN
IGIGLSGHNQQGFGSWNSGTANTGLFNSGTNNIGLFNSGTGNIGIGNSGIGNTGIGNPGV
GNTGLGNSGTGNWGLWNPGTGNMGVANVGTYNTGGYNVGSTNTGIANVGIANTGSYNTGS
TNTGSFNDGDFNTGFYNTGDYNTGFYNTGDVNTGAFIGGNFSNGAFWQSDHQGQWGAHYA
ITVPQIPLLNFSLNIPVNIPIHLDFGTLAVNGFQIPAITLRALGVTHFSVGPIIVPRIAG
TLPVIDINIGDPGGSSSIPITITSGAGPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGS
SSGFGNVGANNSGFWNTAFAGIGNSGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPAN
LSGLSNVGADLTGVLRGPNGSTFNAGLANLGQFNVGSANLGSANLGSANLGSANLGNSNV
GFGNIGNANIGGANIGDFNVGIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGN
TGNNNIGIGLSGDNQIGFGPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGL
FNTGNNNVGIGLTGDGLSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNV
GIGNMGTGGFGVGLSGDSQVGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTG
NTGIGNSGNYNTGLLNAGLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGSY
NTGMANAGDYGTGAFITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPIT
GDITNVSIPAITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGPS
PAINLNIGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGAGSAS
GLLNFGNNSGLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANVSGLLN
IGTNLAGWLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSANIGDFNL
GSANIGDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGFGN
TGNGNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDYNTGI
GNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGFNPGNYNTGY
FNPGNSNTGIANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSEIPWSYDRFQH