Protein Info for Rv0202c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL11

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 966 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 184 to 202 (19 residues), see Phobius details amino acids 207 to 226 (20 residues), see Phobius details amino acids 232 to 254 (23 residues), see Phobius details amino acids 275 to 299 (25 residues), see Phobius details amino acids 311 to 333 (23 residues), see Phobius details amino acids 370 to 392 (23 residues), see Phobius details amino acids 528 to 547 (20 residues), see Phobius details amino acids 557 to 578 (22 residues), see Phobius details amino acids 598 to 616 (19 residues), see Phobius details amino acids 642 to 662 (21 residues), see Phobius details amino acids 668 to 694 (27 residues), see Phobius details PF03176: MMPL" amino acids 118 to 369 (252 residues), 124.7 bits, see alignment E=4.2e-40 amino acids 452 to 703 (252 residues), 121.2 bits, see alignment E=4.7e-39

Best Hits

Swiss-Prot: 100% identical to MMPLB_MYCTO: Heme uptake protein MmpL11 (mmpL11) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mbt:JTY_0208)

Predicted SEED Role

"Transmembrane transport protein MmpL11"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (966 amino acids)

>Rv0202c Probable conserved transmembrane transport protein MmpL11 (Mycobacterium tuberculosis H37Rv)
MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHY
PDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVS
LRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIAN
AERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSM
FGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLIN
TPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSR
WVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPG
ALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLS
VDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAF
LMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVL
AMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFA
GMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLP
KVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKAL
DQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRR
RSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAV
LAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVA
MLEEAR