Protein Info for Rv0145 in Mycobacterium tuberculosis H37Rv

Annotation: Possible S-adenosylmethionine-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 317 TIGR00027: methyltransferase, TIGR00027 family" amino acids 29 to 290 (262 residues), 282.2 bits, see alignment E=2e-88 PF04072: LCM" amino acids 31 to 213 (183 residues), 225 bits, see alignment E=3.7e-71

Best Hits

Swiss-Prot: 100% identical to Y153_MYCTU: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0145 (Rv0145) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtc:MT0153)

Predicted SEED Role

"FIG00823034: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (317 amino acids)

>Rv0145 Possible S-adenosylmethionine-dependent methyltransferase (Mycobacterium tuberculosis H37Rv)
VTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAATNPLIRDEFAKVLVSS
AGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDEYFGAAVDAGVRQVVILAA
GLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVPTARRHAVAVDLRDDWPAALI
AAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSAPGSQVAVEAFTMNTKGNTQRWN
RMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQVHSVSNREEMARLGRAIPQDLVDET
VRTTLLRGRLVTPAQPA