Protein Info for Rv0040c in Mycobacterium tuberculosis H37Rv

Annotation: Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 310 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details PF10738: Lpp-LpqN" amino acids 103 to 270 (168 residues), 223.7 bits, see alignment E=5.6e-71

Best Hits

Swiss-Prot: 100% identical to PR28_MYCTU: Proline-rich 28 kDa antigen (mtc28) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbo:Mb0041c)

Predicted SEED Role

"Proline-rich 28 kDa antigen precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (310 amino acids)

>Rv0040c Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) (Mycobacterium tuberculosis H37Rv)
MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAPVSAPATVPPVQNLTAL
PGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAISGTLRDHLREKGVKLEAQ
RPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNSVYTSNAQLVVYRLIGDFDPA
EAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTYRENDMTLNTSRRHVIATSGADK
YLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAPAQAPAPAPGSAPVGLPGQAPGYPP
AGTLTPVPPR