Protein Info for Rv0017c in Mycobacterium tuberculosis H37Rv

Annotation: Probable cell division protein RodA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 52 to 70 (19 residues), see Phobius details amino acids 80 to 98 (19 residues), see Phobius details amino acids 118 to 135 (18 residues), see Phobius details amino acids 144 to 166 (23 residues), see Phobius details amino acids 186 to 204 (19 residues), see Phobius details amino acids 225 to 242 (18 residues), see Phobius details amino acids 248 to 264 (17 residues), see Phobius details amino acids 269 to 288 (20 residues), see Phobius details amino acids 353 to 373 (21 residues), see Phobius details amino acids 386 to 407 (22 residues), see Phobius details amino acids 419 to 441 (23 residues), see Phobius details PF01098: FTSW_RODA_SPOVE" amino acids 81 to 444 (364 residues), 339.7 bits, see alignment E=9.8e-106

Best Hits

Swiss-Prot: 100% identical to FTSWL_MYCBO: Uncharacterized FtsW-like protein (rodA) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mbb:BCG_0047c)

Predicted SEED Role

"Cell division protein FtsW" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (469 amino acids)

>Rv0017c Probable cell division protein RodA (Mycobacterium tuberculosis H37Rv)
MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFL
TLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLW
TLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLPAALSEQNGAKIWIRLPG
FSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVM
VFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLD
PFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTA
ILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLFIVVGGVTRLIPLTGLTTPWM
SYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV