Protein Info for RS_RS24860 in Ralstonia solanacearum GMI1000

Annotation: altronate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 23 to 94 (72 residues), 40.8 bits, E=4e-14
• PF04295: GD_AH_second
  • amino acids 124 to 266 (143 residues), 147.8 bits, E=3.1e-47
• PF20629: GD_AH_C
  • amino acids 275 to 516 (242 residues), 322.7 bits, E=2e-100

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 100% identity to rso:RSp1615)

MetaCyc: 58% identical to D-arabinonate dehydratase (Herbaspirillum huttiense)
Arabinonate dehydratase. [EC: 4.2.1.5]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• D-galacturonate degradation I (3/5 steps found)
• D-arabinose degradation III (3/6 steps found)
• D-arabinose degradation IV (2/6 steps found)
• superpathway of hexuronide and hexuronate degradation (4/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (13/31 steps found)
• superpathway of pentose and pentitol degradation (12/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.5 or 4.2.1.7

Sequence Analysis Tools

See Q8XPM3 at UniProt or InterPro

Protein Sequence (519 amino acids)

>RS_RS24860 altronate dehydratase (Ralstonia solanacearum GMI1000)
MLQATQADRVTDNGPLIRLNPADNVLIARAALSLGQPLSLGGATVRLRAQVPAGHKIAAC
RIARGEAIRKYDTVIGRAARDIEPGEHVHTHNVELIDFERDPGFCQDVRPVDYLPEAQRA
TFQGIVRPDGRVATRNFIGILASVNCSSSVIKNIAAWFTPQRLAPFPNVDGVVAFAQTSG
CGMSSPSEHFDVLRRTLAGYARHPNLAGVLIVGLGCERNQVADLMASQGLETGKLMHTLV
MQETGGTRATIEAGIDAIRKMLPQANDVARQPVSASHLKIGLECGGSDGFSGITANPALG
AAMDLLVRHGGTAILSETPEIHGVEYMLTRRAVSPEVGQKLLDRLAWWERYTHGHNGQFN
GVVGPGNQQGGLANIFEKSLGSAMKGGTTPLQAVYEYAEPIDRAGFVFMDSPGYDPVAVT
GQIASGANLICFTTGRGSMFGSKPAPTLKLASNTPMFTRLEEDMDINCGRILDGERSVEA
MGQEIFEHILRAASGERTKSELLGLGDHEFVPWHMGIVS