Protein Info for RS_RS17055 in Ralstonia solanacearum GMI1000

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 18 to 40 (23 residues), see Phobius details amino acids 151 to 172 (22 residues), see Phobius details PF00512: HisKA" amino acids 227 to 290 (64 residues), 47.8 bits, see alignment E=1.2e-16 PF02518: HATPase_c" amino acids 337 to 445 (109 residues), 85.1 bits, see alignment E=4.6e-28

Best Hits

KEGG orthology group: K02484, two-component system, OmpR family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to rso:RSc3403)

Predicted SEED Role

"FIG00974455: hypothetical protein"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8XTZ2 at UniProt or InterPro

Protein Sequence (446 amino acids)

>RS_RS17055 two-component sensor histidine kinase (Ralstonia solanacearum GMI1000)
MDGVQGPVKPSLQRRLSLWLSAIIVAVAVAAGGFAFVSAFSEAHELQDDVLRQVGAMFDP
QHLPAASAEAPMADQESRVVVQLLPAPGADAGRASTRATPVFPSTLADGMQTARAGKYNY
RVWVRTLADGQRIAVAQETAVRNETARNSALHTVMPFLILVPILLLAMADVLRKMFAPIR
RLAHEVDQRDERQLHAIAPDAVPAEVRPFVVAINRLLARVAQSVQAQHRFVADAAHELRT
PLTALSLQAERLGEAPMSAAAQERLAALRQGIERSRALLEQLLTLARAQADTQAPAGAVS
VQRVFRSVLEDLMPLAEAKRLDLGVTTDADARVRAGELDLFVILRNLVDNAIRYTPDGGS
IDLSLQTDGDLAHITVQDTGPGIPASERARVFDAFYRVLGNGATGSGLGLSIVGTLVQRL
GGEVALDEAAGTASGLRATVRLPLAE