Protein Info for RR42_RS37310 in Cupriavidus basilensis FW507-4G11

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1075 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 314 to 335 (22 residues), see Phobius details PF03924: CHASE" amino acids 76 to 263 (188 residues), 161.5 bits, see alignment E=6.2e-51 PF08448: PAS_4" amino acids 364 to 459 (96 residues), 23.2 bits, see alignment E=2.1e-08 PF13426: PAS_9" amino acids 367 to 458 (92 residues), 31.8 bits, see alignment E=4.2e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 631 to 790 (160 residues), 142.3 bits, see alignment E=1.2e-45 PF00990: GGDEF" amino acids 634 to 789 (156 residues), 160 bits, see alignment E=1.3e-50 PF00563: EAL" amino acids 813 to 1045 (233 residues), 249.2 bits, see alignment E=1.1e-77

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YRC2 at UniProt or InterPro

Protein Sequence (1075 amino acids)

>RR42_RS37310 diguanylate cyclase (Cupriavidus basilensis FW507-4G11)
MKLPSISPVLLSLLVAAAGALATGGAWRGMHTLEAEVARDDFEAVFSPVFSALQRRLQDN
EQLLRGTTGLFAADPALTREQWRNYLYTTQLDDLPPGTHSIGYARLTPPRELDWLVETIR
REGQPGFEVYPLGPRDVYAPVVYVEPFAGRITRALGFDIMSDPVRRAAAEAARDSGEARL
SAGVELTRESETQAPQRGAVLYLPVYGSGLPLNTPTQRQLAVTGYVYTSLRLEDLLRGVG
LPAAGTLSLLLYEGRDTNPGALLAGDAEPVPAGAPVPAPLLQAERELTYGGRVWTLRATT
TPAFESAHRPRRSMLVLAGGTAGTLLLAWIVFGLARQRRRAWQLAARVRQGRQADSALQR
AGLASASDAFLVCDAGGRVQIASAAATALFGKAPDQFPGTLIATLLPDAATLAATALEGR
LESHARRSDGTIIPVRVAVTPVPAAGPGRVLWVVTDLSAIRRAELVAADVAERSARVLDH
TALCVITFDRNGTVTGINRAGQRMLWYQASEVAAGMRYLDFLDPKEVTARAAVLTNELGE
PVAPGLAAVVGKARLGLTDEQEWTYVRKGGSRLPVQLTLTALPEAHVPGGTGDPPAPAFA
GEAGIGGLDAGGYLAIAHDLTERKRADEYIRHLAHHDALTGLPNRAQLHARTELVLQRAL
RKGERIALLLLDLDQFKRINESLGHHIGDEVLRIVADRLKAAVRYADLVARMGGDEFVVV
LDPLSQDSEAELVAAKILARLSEDLQLGNQRLRVTPSIGMVLCPDDGDNLADLLRNADAA
MYAAKRRGGAQLSRFSSEMAEASMARFTIEGLLRRALATQAFKLRYQPIVDTATLRIAGV
EALIQWETPERGVIPPTEFIPIAEQSGLIMPLGEWILATACREIQQLRSELGVELDVAVN
ISPLQLRQEGFPAMVTQCLAAAGLPASSLTIEVTEGILIEGGSKTMDTFERVRALGVGLS
IDDFGTGYSGLSYLTRLPIDKLKIDKSFVDDVAHDEHHQAVAAAIITLGHQLHLQVVAEG
VESPAQFAFLREHGCDAVQGYLFCQAVPLAGLMEICAAGGEVTMRAWAQRVPAAD