Protein Info for RR42_RS36850 in Cupriavidus basilensis FW507-4G11

Annotation: chaperone protein HchA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 293 PF01965: DJ-1_PfpI" amino acids 77 to 198 (122 residues), 27.2 bits, see alignment E=1.6e-10

Best Hits

Swiss-Prot: 60% identical to HCHA_PSEAE: Protein/nucleic acid deglycase HchA (hchA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K05523, molecular chaperone HchA (Hsp31) (inferred from 93% identity to reh:H16_B1347)

MetaCyc: 61% identical to protein/nucleic acid deglycase 1 (Escherichia coli K-12 substr. MG1655)
GLYOXIII-RXN [EC: 4.2.1.130]; RXN-17630 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]

Predicted SEED Role

"Chaperone protein hchA"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.124 or 4.2.1.130

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YGF8 at UniProt or InterPro

Protein Sequence (293 amino acids)

>RR42_RS36850 chaperone protein HchA (Cupriavidus basilensis FW507-4G11)
MTSQTDSKQPTPDPAERNAFFPSPYSLSQFTSPKSNLADADYPDAYQGGRWKVLLVAADE
RYLLTGNGTFFSTGNHPVETLLPMYHLDRAGFEFDIATLSGNPAKFEWWAFPSEDAEIKA
LYAKYEQKFQQPLKLADVVNSLNKDADYIAVFVPGGHGALMGLPFSADMKATLQWAMQND
KYVITLCHGPAALLSASVDEPNGGDLFRGYRICAFPDAMDKQTPDIGYMPGPLRWFFGEK
LAAMGVEIVNTGIDGSTFRDRKLLTGDSPLAANNLGKLAARVLLDEVQNTGGR