Protein Info for RR42_RS36125 in Cupriavidus basilensis FW507-4G11

Annotation: IclR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 282 TIGR02431: beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family" amino acids 32 to 277 (246 residues), 346.3 bits, see alignment E=4.2e-108 PF09339: HTH_IclR" amino acids 39 to 88 (50 residues), 50.4 bits, see alignment 1.5e-17 PF01614: IclR" amino acids 151 to 276 (126 residues), 121.8 bits, see alignment E=1.8e-39

Best Hits

Swiss-Prot: 43% identical to PCAR_PSEPU: Pca regulon regulatory protein (pcaR) from Pseudomonas putida

KEGG orthology group: K02624, IclR family transcriptional regulator, pca regulon regulatory protein (inferred from 82% identity to reh:H16_B0167)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YS80 at UniProt or InterPro

Protein Sequence (282 amino acids)

>RR42_RS36125 IclR family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MASPAAPDNSDHPATDAPVAPAAAPGPDKPSDTYVQSFARGLSVIRAFDAQHPAQTLSEI
AQASGLTRAGARRILLTLVGLGYVRADGRLFRLTPKILDLGFAYLTSMPFWNLAEPIMEA
LSQEVRESCSISVLDGTEIVYVLRVPARKIMTINLSIGSRLPAYCSSMGRVLLAGLPLEE
LDRVLGASELRARTSRTVTDPAELKAIIAGIRTRGWAQNDQELEEGLVSLAAPIRNRAGQ
VIAAINISGQANRTSADDMASSFLPALLAASEKISNLISLRS