Protein Info for RR42_RS35350 in Cupriavidus basilensis FW507-4G11

Annotation: copper ABC transporter ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 818 transmembrane" amino acids 168 to 186 (19 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 229 to 253 (25 residues), see Phobius details amino acids 266 to 285 (20 residues), see Phobius details amino acids 420 to 442 (23 residues), see Phobius details amino acids 448 to 471 (24 residues), see Phobius details amino acids 764 to 784 (21 residues), see Phobius details amino acids 790 to 811 (22 residues), see Phobius details PF04945: YHS" amino acids 64 to 106 (43 residues), 47.3 bits, see alignment 4.2e-16 PF19335: HMBD" amino acids 123 to 148 (26 residues), 49.2 bits, see alignment (E = 1e-16) TIGR01511: copper-translocating P-type ATPase" amino acids 212 to 814 (603 residues), 581.7 bits, see alignment E=3.6e-178 TIGR01525: heavy metal translocating P-type ATPase" amino acids 230 to 813 (584 residues), 605.3 bits, see alignment E=2.7e-185 TIGR01494: HAD ATPase, P-type, family IC" amino acids 274 to 797 (524 residues), 287.6 bits, see alignment E=2.9e-89 PF00122: E1-E2_ATPase" amino acids 303 to 484 (182 residues), 193.1 bits, see alignment E=8.1e-61 PF00702: Hydrolase" amino acids 501 to 718 (218 residues), 121.6 bits, see alignment E=1.4e-38

Best Hits

Swiss-Prot: 58% identical to COPA_LEGPH: Copper-exporting P-type ATPase (copA) from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 86% identity to bge:BC1002_4328)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YQB4 at UniProt or InterPro

Protein Sequence (818 amino acids)

>RR42_RS35350 copper ABC transporter ATPase (Cupriavidus basilensis FW507-4G11)
MSDQRGKDTDSHNQHASGGQSLGNEHDHGSHHQHGNSNPSAPESHVRCEHNHGHAAPDAA
TQLNDPVCGMSVTADSHFHSEHDGVRYFFCSESCQKKFEAEPLKYIAPAVDASVAFASEG
TIYTCPMHLEIRQDHPGNCPKCGMTLEPIIPGLDEEENPELVDFSHRFWWTLPLTVVVFI
LAMFGHQLDLMEVSTQSWVELLLATPVVLWAGLPFFQRCMQSFINRSPNMWTLIGLGTGA
AYLYSVIATVAPGVFPEAFAAHGRIGVYFEAAAVIISLTLVGQLLELKARSQTSAAIKSL
LGLAPKTARRINADGTEEDVPLTHVHVGDTLRVRPGEKVPVDGVVTEGSSSLDESMITGE
PIPVTKRVGDHVIGATMNTSGSLVIKSEKVGSQTVLSQIIQMVAQAQRSKAPMQRMADKV
AGVFVLAVVGIALITFFAWGFFGPEPSWVYGLINAVAVLIIACPCALGLATPMSIMVASG
KGASNGMLFRDAAAIENLRKVDTLIVDKTGTLTEGRPTFERAIGANGFTEEEVLRLAASL
DQGSEHPLAATIVEAARQRNLVLQKAENFESGTGIGVRGIVAGRKLALGNTALMQAEGIG
TDSLAGEGDTLRAQGASVMYLAVDGKLAGILAVSDPVKPTTPEALARLREVGIRVVMATG
DGVVTAKSVAAKLGIDEFHGEVKPADKLALVSKFQAEGRVVAMAGDGINDAPALAKADVG
IAMGTGTDVAMNSAQVTLVKGDLRGIARARELSEATIWNMKQNLGFAFVYNALGVPLAAG
VLYASTGWLLSPMIAALAMSLSSASVVSNALRLRKAKI